We have a large population of HCV genotype 4 patient on hemodialysis that need to clear the virus before kidney transplant?
The available limited data suggest an increase of 1000% in ESRD
Via the US FDA comes this link with up to date info
http://hepatitiscnewdrugresearch.com/fda-sofosbuvir.html
Thank you for your reply
Is tehere any clinical experience or data about sofosbuvir plus simeprevir combinaton therapy in liver transplant recipients with recurrent hepatitis C and end stage renal failure ...
Here is the current information on Sofosbuvir from the manufacturer-
http://www.gilead.com/~/media/Files/pdfs/medicines/liver-disease/sovaldi/sovaldi_pi.pdf
NB Section 8.6
We have experience with Sofobuvir/pegasys/Ribavirin after liver transplant
Buttom line: poor tolerability
dear professor Hussien Elsiesy
Sofosbuvir-Containing Regimens including Patients with Renal Disease HCV-TARGET (Renal Disease)
denoting that sofo or veikera give 100 % in mild and moderate renal damage
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