I know that creatine supplementation has been found to be beneficial in those with depression and chronic fatigue. I was wondering if there were clues in clinical laboratory measurements, like low serum creatinine, that might indicate who would benefit from supplementation.
Blood creatinine levels are affected by too many things (e.g., kidney function, body composition, meat intake). I'd be wary about trying to determine creatine supplementation requirements on the basis of the blood creatinine level.
Dear Jason,
As Dr. Warren explained previously, serum creatinine concentrations are quite affected by several mechanisms. Interestingly, a very recent clinical trial by Ostojic et al. (2020) aimed to compare the effects of creatine monohydrate, creatine nitrate and creatine nitrate + creatinine on single dose pharmacokinetics and 5-days supplementation on skeletal muscle creatine levels, clinical chemistry, and subjective side effects in young healthy men. The authors found that creatine nitrate + creatinine might be a preferred and relatively safe alternative to traditional creatine formulations for improved creatine bioavailability in the blood and skeletal muscle after single‐dose and 5‐days interventions. Probably based on the Le Chatelier's principle, this study "provided a first indirect proof that creatinine might be hydrolyzed back to creatine in humans, as noted via favorable pharmacokinetics for serum creatine in a single‐dose creatine nitrate + creatinine trial, although studies using isotope‐labeled creatinine are needed to address this."
https://onlinelibrary.wiley.com/doi/full/10.1002/fsn3.1237
- Badges
- Science topic
- Similar topics
- Biological Science
- Biochemistry
- Biochemical Techniques
- Analytical Chemistry
- pH