Dear Shilpakala,

In VETERINARY field,

Considering Body Condition Score, BCS (using 1-5 scale; 1- emaciated to 5-obese) in higher (BCS=2.80, average) and lower conditioned dairy cows (BCS=2.30), we found "only a weak correlation" between the routine blood parameters (carbohydrates, proteins and lipids and some enzymes) and thyroid hormone levels during the early lactation period. Our results suggested that in the early lactation period, the active thyroid hormone was not directly involved in the metabolism regulation in cows.

For further details, please see the attached file.

Good luck & Regards,

Omer

Thank you Omer sir but in our study only menopause and premenopause women included. . So alteration of thyroid profile will be there and I need the possible reasons. ..

Dear Shilpakala,,

I think that there is definitely a relationship . In  hyperinsulinemic/diabetic patients  the epimerase enzyme activity increased . This implies an increase of the conversion of myo - inositol to D - chiro - inositol . This represents a defense mechanism to reduce insulin resistance . At the same time , however, the reduction of myo - inositol determines a reduction of myo - inositolphsphoglycan promoters of the signals for both FSH and TSH . This results in a resistance of the thyroid to TSH with consequent increase of the same . I hope to be liked . BR Vittorio