Is there any other method than Tail bleeding assay to analyze pharmacodynamics for Hemophilia A in mouse model?

11 November 2016 1 9K Report

I am trying to find other animal model study other than tail bleeding assay to analyze pharmacodynamics in hemophilia A mouse model (FVIII KO). I am aware of transection model, however I want to know whether there are different ways to analyze pharmacodynamics of recombinant FVIII.

Nehal Aly Afifi

Hi Dr.Hansang Row

I think you must make the Safety Pharmacology Test, the single dose toxicity test, as well as the tolerance Test. Please follow this attached paper as a detailed method

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