Hi Jess,

there are a few mouse models that I am aware off that can be used as recipients of human cell line transplants. However, most of them are more or less immunocompromised to not reject human cells. There are efforts to establish "humanized" mouse models, but as with immunocompromised mouse models, there are certain drawbacks to these models (doi 10.1158/2159-8290.CD-18-0044). Which mouse model you should use highly depends on your scientific question.

A few commonly used mouse models for human cell line transplants are:

• Athymic nude: Deficient in T-cells (still have B-cells and NK cells)
• SCID: Deficient in T-cells and B-cells
• Rag-deficient: Lack functional T-cells and B-cells
• IL2Rγnull : Lack NK cells

These mouse strains are sometimes bred to combine the genetic mutations, leading to increased immunodeficiency.

Pat