All enzymes undergoes post-translational modification (PTM) to become a functional mature enzyme. Is there any enzyme which doesn't undergo PTM? any exceptional enzyme?
I do not think it is a general rule that all enzymes undergo post-translational modification. It is definitely not true of many (perhaps most) cytoplasmic bacterial enzymes. I know this because the measured masses of many bacterial proteins expressed in E. coli match the predicted masses precisely. (Caveat: reversible covalent modification such as lysine carboxylation may not be observed by this technique.)
There is surely a lot more PTM going on in eukaryotic cells, but I doubt that every cytolasmic enzyme is modified. There may also be cases where a protein is sometimes modified in an accidental way (e.g. phosphorylation) that has no significant bearing on its function.
If you disregard removal of signal peptides and formation of disulfide bonds, then you can probably include some noncytoplasmic enzymes among those that undergo no functional PTM.
I do not think it is a general rule that all enzymes undergo post-translational modification. It is definitely not true of many (perhaps most) cytoplasmic bacterial enzymes. I know this because the measured masses of many bacterial proteins expressed in E. coli match the predicted masses precisely. (Caveat: reversible covalent modification such as lysine carboxylation may not be observed by this technique.)
There is surely a lot more PTM going on in eukaryotic cells, but I doubt that every cytolasmic enzyme is modified. There may also be cases where a protein is sometimes modified in an accidental way (e.g. phosphorylation) that has no significant bearing on its function.
If you disregard removal of signal peptides and formation of disulfide bonds, then you can probably include some noncytoplasmic enzymes among those that undergo no functional PTM.
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