Besides apparent differences in prognosis (which cannot really be objectivated nowadays) and "more" necrosis in histology samples, is there any objective clinical or pathological difference?
It is simply the clinical course. ADEM is monophasic, and replaces by large the old terms post- or parainfectious encephalitis. Marburg variant is a variant of MS with foudrouyant clinical presentation, and relapses, be it relatively benign or another big relapse. Neuropathology makes no real difference except for the Hurst variant of ADEM.
I hope that following paper be useful.
Regards
Article Fulminant Demyelinating Diseases
My little knowledge is that Marburg is an acute MS variant with numerous large multifocal demyelinating lesions occurring in the deep white matter. The clinical course seems to be different; being more fulminant & death is inevitable without aggressive immunotherapy. ADEM in the contrary is more of transient and self limiting disease.
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