Nano liposome is a minute particles can be used in molecular biology research and in nanotechnology projects. This little molecule can be used as a carrier or as itself in cancer research to kill cancer cells. The available procedure to prepare this molecule is so expensive. I wonder if there is cheaper method to obtain such liposome.
Liposomes are infact cheaper because the basic lipids (phosphocholines) that go into its preparation can be obtained in bulk at very low cost. As far as preparation methods are concerned, number of industrial scale preparations are available such as mechanical (microfluidizer, high-pressure homogenization, ultrasonic, extrusion) or by replacing organic solvent by aqueous media (ethanol injection, reverse-phase evaporation, ether infusion) etc...For the purpose of lab-scale research, they can be prepared very easily without any huge investment with hand-held extruders, reverse-phase evaporation, sonication etc.. There are also a number of other lipid nanoparticles that can be industrially prepared with ease, please see my Advanced materials 2012 review article. A number of modifications including targeting ligands can be used to target cancer. Again, for the latest overview of this area, see my Advanced materials 2012 review and other liposome research from my publications.
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Thank you Dr Shroff for these valuable information.I tried to download your article but I got just the cover page. Could you please send e your article to my e mail [email protected]. thank you
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