ANK3 gene was found to be changed in some psychological disorders such as bipolar disorders, depression and schizophrenia. I need any article that confirms this fact.
Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Diseases associated with ANK3 include mental retardation, autosomal recessive, intellectual disability-hypotonia-spasticity-sleep disorder syndrome. Among its related pathways are Transport to the Golgi and subsequent modification and Developmen of brain and peripheral nervous system.
These are the articles which support the facts related to your query
1. Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder. (PMID: 19088739) Schulze T.G. … McMahon F.J.(Mol. Psychiatry 2009)
2. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. (PMID: 18711365) Ferreira M.A. … Craddock N.(Nat. Genet. 2008)
3. Chromosomal localization of the ankyrinG gene (ANK3/Ank3) to human 10q21 and mouse 10. (PMID: 7665168) Kapfhamer D. … Burmeister M.(Genomics 1995)
4. Association of a risk allele of ANK3 with cognitive performance and cortical thickness in patients with first-episode psychosis. (PMID: 24016415) Cassidy C. … Joober R.(J Psychiatry Neurosci 2014)
5. Cognitive effects of the ANK3 risk variants in patients with bipolar disorder and healthy individuals. (PMID: 24655771) Hori H. … Kunugi H.(J Affect Disord 2014)
6. Analysis of ANK3 and CACNA1C variants identified in bipolar disorder whole genome sequence data. (PMID: 24716743) Fiorentino A. … Gurling H.M.(Bipolar Disord 2014)
7. ANK3 gene expression in bipolar disorder and schizophrenia. (PMID: 24809399) Wirgenes K.V. … Djurovic S.(Br J Psychiatry 2014)
8. Genetic association of LMAN2L gene in schizophrenia and bipolar disorder and its interaction with ANK3 gene polymorphism. (PMID: 24914473) Lim C.H. … Mohamed Z.(Prog. Neuropsychopharmacol. Biol. Psychiatry 2014)
9. Cis-acting regulation of brain-specific ANK3 gene expression by a genetic variant associated with bipolar disorder. (PMID: 22850628) Rueckert E.H. … Sklar P.(Mol. Psychiatry 2013)
10. Homozygous and heterozygous disruptions of ANK3: at the crossroads of neurodevelopmental and psychiatric disorders. (PMID: 23390136) Iqbal Z. … Rooms L.(Hum. Mol. Genet. 2013)
11. Family-based association of an ANK3 haplotype with bipolar disorder in Latino populations. (PMID: 23715300) Gonzalez S.D. … Escamilla M.(Transl Psychiatry 2013)
12. Independent Modulation of Engagement and Connectivity of the Facial Network During Affect Processing by CACNA1C and ANK3 Risk Genes for Bipolar Disorder. (PMID: 24108394) Dima D. … Frangou S.(JAMA Psychiatry 2013)
13. Sequencing of the ANKYRIN 3 gene (ANK3) encoding ankyrin G in bipolar disorder reveals a non-conservative amino acid change in a short isoform of ankyrin G. (PMID: 22328486) Dedman A. … Gurling H.(Am. J. Med. Genet. B Neuropsychiatr. Genet. 2012)
14. Bipolar disorder ANK3 risk variant effect on sustained attention is replicated in a large healthy population. (PMID: 22498896) Hatzimanolis A. … Stefanis N.C.(Psychiatr. Genet. 2012)
15. ANK3 and CACNA1C--missing genetic link for bipolar disorder and major depressive disorder in two German case-control samples. (PMID: 22647524) Kloiber S. … Lucae S.(J Psychiatr Res 2012)
16. Mutations of ANK3 identified by exome sequencing are associated with autism susceptibility. (PMID: 22865819) Bi C. … Sun Z.S.(Hum. Mutat. 2012)
17. ANK3 as a risk gene for schizophrenia: new data in Han Chinese and meta analysis. (PMID: 23109352) Yuan A. … Yu S.(Am. J. Med. Genet. B Neuropsychiatr. Genet. 2012)
18. The cognitive impact of the ANK3 risk variant for bipolar disorder: initial evidence of selectivity to signal detection during sustained attention. (PMID: 21304963) Ruberto G. … Frangou S.(PLoS ONE 2011)
19. Association of ANK3 with bipolar disorder confirmed in East Asia. (PMID: 21438140) Takata A. … Kato T.(Am. J. Med. Genet. B Neuropsychiatr. Genet. 2011)
20. The CACNA1C and ANK3 risk alleles impact on affective personality traits and 21. startle reactivity but not on cognition or gating in healthy males. (PMID: 21676128) Roussos P. … Bitsios P.(Bipolar Disord 2011)
22. ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype. (PMID: 21767209) Lett T.A. … MA1ller D.J.(World J. Biol. Psychiatry 2011)
23. Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples. (PMID: 21972176) Tesli M. … Andreassen O.A.(Am. J. Med. Genet. B Neuropsychiatr. Genet. 2011)
24. No association between bipolar disorder risk polymorphisms in ANK3 and CACNA1C and common migraine. (PMID: 21395576) WAPber-BingAPl C. … Collier D.A.(Headache 2011)
25. Evidence for cis-acting regulation of ANK3 and CACNA1C gene expression. (PMID: 20636642) Quinn E.M. … Morris D.W.(Bipolar Disord 2010)
Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Diseases associated with ANK3 include mental retardation, autosomal recessive, intellectual disability-hypotonia-spasticity-sleep disorder syndrome. Among its related pathways are Transport to the Golgi and subsequent modification and Developmen of brain and peripheral nervous system.
These are the articles which support the facts related to your query
1. Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder. (PMID: 19088739) Schulze T.G. … McMahon F.J.(Mol. Psychiatry 2009)
2. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. (PMID: 18711365) Ferreira M.A. … Craddock N.(Nat. Genet. 2008)
3. Chromosomal localization of the ankyrinG gene (ANK3/Ank3) to human 10q21 and mouse 10. (PMID: 7665168) Kapfhamer D. … Burmeister M.(Genomics 1995)
4. Association of a risk allele of ANK3 with cognitive performance and cortical thickness in patients with first-episode psychosis. (PMID: 24016415) Cassidy C. … Joober R.(J Psychiatry Neurosci 2014)
5. Cognitive effects of the ANK3 risk variants in patients with bipolar disorder and healthy individuals. (PMID: 24655771) Hori H. … Kunugi H.(J Affect Disord 2014)
6. Analysis of ANK3 and CACNA1C variants identified in bipolar disorder whole genome sequence data. (PMID: 24716743) Fiorentino A. … Gurling H.M.(Bipolar Disord 2014)
7. ANK3 gene expression in bipolar disorder and schizophrenia. (PMID: 24809399) Wirgenes K.V. … Djurovic S.(Br J Psychiatry 2014)
8. Genetic association of LMAN2L gene in schizophrenia and bipolar disorder and its interaction with ANK3 gene polymorphism. (PMID: 24914473) Lim C.H. … Mohamed Z.(Prog. Neuropsychopharmacol. Biol. Psychiatry 2014)
9. Cis-acting regulation of brain-specific ANK3 gene expression by a genetic variant associated with bipolar disorder. (PMID: 22850628) Rueckert E.H. … Sklar P.(Mol. Psychiatry 2013)
10. Homozygous and heterozygous disruptions of ANK3: at the crossroads of neurodevelopmental and psychiatric disorders. (PMID: 23390136) Iqbal Z. … Rooms L.(Hum. Mol. Genet. 2013)
11. Family-based association of an ANK3 haplotype with bipolar disorder in Latino populations. (PMID: 23715300) Gonzalez S.D. … Escamilla M.(Transl Psychiatry 2013)
12. Independent Modulation of Engagement and Connectivity of the Facial Network During Affect Processing by CACNA1C and ANK3 Risk Genes for Bipolar Disorder. (PMID: 24108394) Dima D. … Frangou S.(JAMA Psychiatry 2013)
13. Sequencing of the ANKYRIN 3 gene (ANK3) encoding ankyrin G in bipolar disorder reveals a non-conservative amino acid change in a short isoform of ankyrin G. (PMID: 22328486) Dedman A. … Gurling H.(Am. J. Med. Genet. B Neuropsychiatr. Genet. 2012)
14. Bipolar disorder ANK3 risk variant effect on sustained attention is replicated in a large healthy population. (PMID: 22498896) Hatzimanolis A. … Stefanis N.C.(Psychiatr. Genet. 2012)
15. ANK3 and CACNA1C--missing genetic link for bipolar disorder and major depressive disorder in two German case-control samples. (PMID: 22647524) Kloiber S. … Lucae S.(J Psychiatr Res 2012)
16. Mutations of ANK3 identified by exome sequencing are associated with autism susceptibility. (PMID: 22865819) Bi C. … Sun Z.S.(Hum. Mutat. 2012)
17. ANK3 as a risk gene for schizophrenia: new data in Han Chinese and meta analysis. (PMID: 23109352) Yuan A. … Yu S.(Am. J. Med. Genet. B Neuropsychiatr. Genet. 2012)
18. The cognitive impact of the ANK3 risk variant for bipolar disorder: initial evidence of selectivity to signal detection during sustained attention. (PMID: 21304963) Ruberto G. … Frangou S.(PLoS ONE 2011)
19. Association of ANK3 with bipolar disorder confirmed in East Asia. (PMID: 21438140) Takata A. … Kato T.(Am. J. Med. Genet. B Neuropsychiatr. Genet. 2011)
20. The CACNA1C and ANK3 risk alleles impact on affective personality traits and 21. startle reactivity but not on cognition or gating in healthy males. (PMID: 21676128) Roussos P. … Bitsios P.(Bipolar Disord 2011)
22. ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype. (PMID: 21767209) Lett T.A. … MA1ller D.J.(World J. Biol. Psychiatry 2011)
23. Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples. (PMID: 21972176) Tesli M. … Andreassen O.A.(Am. J. Med. Genet. B Neuropsychiatr. Genet. 2011)
24. No association between bipolar disorder risk polymorphisms in ANK3 and CACNA1C and common migraine. (PMID: 21395576) WAPber-BingAPl C. … Collier D.A.(Headache 2011)
25. Evidence for cis-acting regulation of ANK3 and CACNA1C gene expression. (PMID: 20636642) Quinn E.M. … Morris D.W.(Bipolar Disord 2010)
Thank you Dr Pradhan for you kind cooperation and for this nice comment. I need to collect any information about the genetic of stress, violence and aggression because I prepared myself to establish a research centre dealing with such cases in Iraq. It is not easy for me to obtain scientific article here due some difficult conditions, therefore I may ask colleagues in the Researchgate to help me by providing me with such articles. Best Wishes
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