I'm unable to find an objective definition Chronic Kidney Disease-Mineral Bone Disease (CKD-MBD)?
Has anyone defined CKD-MBD objectively yet?
Dear Sir, All CKD patients will or have to undergo Bone Mineral Disease and it is always supported by oral tablets called Calcitriol and a mandatory serum calcium level is evaluated by blood test every fortnight.
As there is reduced kidney function there is tremendous alteration in the calcium balance in the blood as there is also HUS ( Hemolytic Urea Syndrome) accompanied by most or all of the CKD patients causing anemia which again causes imbalance in calcium reabsorption and storage and metabolism of the same.
Sir, you should understand that these are complication arising due to insufficient kidney function and all such complications are understood since it is expected to happen and never confirmative, so a definition is to be formed to our understanding and never said to be compulsory. Thanks.
Hi
I send you the guidelines as pdf. National Kidney Fundation defines and classifies CKDMBD as below:
"KDIGO classification of CKD–MBD and renal osteodystrophy
Definition of CKD–MBD
A systemic disorder of mineral and bone metabolism due to CKD manifested by either one or a combination of the following:
-Abnormalities of calcium, phosphorus, PTH, or vitamin D metabolism.
-Abnormalities in bone turnover, mineralization, volume, linear growth, or strength.
- Vascular or other soft-tissue calcification.
Definition of renal osteodystrophy
-Renal osteodystrophy is an alteration of bone morphology in patients with CKD.
- It is one measure of the skeletal component of the systemic disorder of CKD–MBD that is quantifiable by histomorphometry of bone biopsy.
CKD, chronic kidney disease; CKD–MBD, chronic kidney disease–mineral and bone disorder; KDIGO, Kidney Disease: Improving Global Outcomes; PTH, parathyroid hormone.
Kind regards, Michaela
The term Chronic Kidney Disease -Mineral and Bone Disorder (CKD-MBD) be used to describe a broader clinical syndrome that develops as a systemic disorder of mineral and bone metabolism due to CKD, which is manifested by abnormalities in bone and
mineral metabolism and/or extra-skeletal calcification.The initial evaluation of CKD-MBD should include PTH, calcium, phosphorus, alkaline phosphatase, bicarbonate, and imaging for soft tissue calcification.The US National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF-KDOQI) published clinical practice guidelines provided recommended target ranges for various markers of MBD, such as iPTH 150-300 pg/mL, total serum calcium
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