Yuan Yu
Thank you so much for taking the time to explain such important data in details. I have a better idea now. What I get for your answer is that countries that with younger populations and which have implemented quarantine efficiently (to stop direct contact), should be able to control infection rates.
Also, some health care workers suggested the use of antiseptic mouthwash to reduce the viral load. Do you think that pre-existing oral pathology like gingivitis accelerate infection? Similarly, do you think that smoker's lung has a higher susceptibility to the virus?
Yuan Yu
Dear Dr., thanks for your response. You've included some very interesting and brilliant pieces of information.I am now very interested to follow this very useful dialogue.
Totally agree with dr. shi.
Although wuhan was the center of Covid-19, lower mortality in China has been reported comparing with Italy. The fast decision of wuhan lockdown and the people’s great cooperation by staying home during epidemic In China have made important difference to control infection and mortality rate.
DISCUSSION:
Well analyzing the data previously described and making a clear comparison between common geographic spaces between the appearance of covid-19 outbreaks and the activation and existence of antennas and the emission of signals to provide service in 5G technology. As also the coincidence in the timeline I would like to be able to highlight this situation since my hypothesis is as follows:
Consulting the sources on the incidence of waves on protein structures and cells of different kinds, an acceleration in metabolic processes and, consequently, a greater speed in the case of a virus of its spread, the studies carried out regarding safety by Radiation was fixed only in the incidence in the genome or in the penetration capacity of these waves derived from the use of terminals, etc. That is, in the direct incidence on the health of these waves, studying the possible impact on DNA chains and also the heating of tissues at the local level, such as the skin in places where for example a terminal is in contact with that part of the body, as well as the degree of penetration that these types of waves possess.
But unfortunately I have not found any study in terms of safety, which takes into account the interaction of these waves with single-celled organisms, and may produce an electroporesis process induced by exposure to this type of wave.
The only study that I have found is not in reference to the safety and prevention of 5G technology, it only refers to the study and the incidence that it has on cells and different protein markers and the activation exerted by waves that are casually similar or even lower than those that emits 5G antennas.
On the other hand, I would like to emphasize that probably and if the relationship between the interaction between these waves and the acceleration in the metabolism of the nexus is confirmed, in this case Covid-19 with the cells of both the respiratory epithelium and the gastric epithelium due to exposure to these waves emitted by antennas that serve the 5G technology. Since a circumstance similar to the one that occurs in the electroporesis processes induced in laboratory tests for the study of other fields could be produced, which is also highly demonstrated as that process in wave induction is a facilitator for the nexus and transform the walls of cellular organisms much more permeable, facilitating their connection and subsequent union.
Surely this virus would be among us a long time ago but if the emissions from these antennas made their metabolic rate and their interaction somehow "doped", because these slings would not only exert a greater activation towards the virus since it is a entity that needs to colonize continuously in order to continue its expansion and replication within the cell.
Well, if these waves degraded the membranes of the cells that are part of the respiratory epithelium, they would facilitate contact and the link with the virus and their incubation time and success rate in colonizing new cells would be tremendous.
It would not give our immune system time to react, it would also explain the behavior of the virus, which now seems to behave somewhat erratically without the proper data and does not follow a natural pattern.
Jose Luis Minguillón Hernández Thank you. That is an interesting theory, but does it explain the variation in cases numbers within the same continent? There is also another interesting theory that says countries with history of malaria are more able to resist infection because of herd immunity.
Najla Saeed Dar-Odeh, Hello again there is conflicting data regarding the spread of the virus. But with the data that I have been able to obtain so far, there seems to be a correlation between the number of cases and the implantation of these antennas in time and their quantity.
I have opened several questions to further refine this information and continue investigating it with weight data.
Jose Luis Minguillón Hernández Yes if you think there is a correlation you should pursue it. The genome sequence of the virus is said to be different between the countries and this has reflected on its virulence.
If the virus had an external agent that facilitated entry to the cell, its growth rate and its ability to mutate would also be increased since it would be able to replicate faster and give it more opportunities to mutate. It would be interesting to have that exact information. To assert that behavior and the sequence of its genome in different geographical situations.
Article Genome analyses help track coronavirus' moves
This may be helpful
Following natural disasters such as earthquakes and tornadoes, the initial reports indicate only a few people died but as more information becomes available the death toll invariably rises. It will be the same with the coronavirus. We will all be wiser after the event with investigators establishing what the true impact on different societies was and why they differed all to be followed by “experts” saying this should or should not have been done. It is a new threat and will take time to understand what are the best measures to take. Is social distancing 2 m, or as recently suggested 6 m? Will the UK death toll be 200,000 as was reported last week or 5,000 as is being reported this week? The answers to all our questions will be revealed but not necessarily in time to be of assistance. Meanwhile, self-isolation to the maximum extent feasible, improved hygienic practices, and not compromising our immune systems are probably all individuals can do until a vaccine is developed or the virus mutates to a less threatening form. If we come down with the virus then hopefully our health services will be able to cope.
https://blogs.scientificamerican.com/observations/we-have-no-reason-to-believe-5g-is-safe/
Exposure Limits: The underestimation of absorbed cell phone ...
In this RG question there are some attempt to recognize the factors of impressive mortality rate in some countries (as Lombardia, Italy; Madrid prov., Spain; Iran; ..).
An element to be considered is the absence of unified protocols by WHO, for a numbers of variables (infect recognition/counts; tests; death ratio; ...).
https://www.researchgate.net/post/The_novel_Coronavirus_in_N_Italy_Lombardia_COVID19_2019nCoV_SARSCoV2_shows_a_fatality_rate_compatible_with_SARS_Why2
The current estimates of numbers of COVID-19 cases and deaths are very inaccurate. The sensitivity and specificity of the diagnostic tests for COVID-19 are not yet known in vivo. There are reports of very high sensitivity and specificity in vitro. However a number of confounding factors (e.g. the stage of illness and the way the swab was taken) mean that the false negative rate of these tests may be high in clinical practice.
The numbers of cases reported will also depend on strategies used for screening. Many countries are only screening symptomatic patients presenting to healthcare facilities. Others are attempting to screen a significant proportion of the population.
I believe the total number of cases of COVID-19 is significantly higher than that being reported. There are many confounding factors (both political and diagnostic) that make the initial number of deaths reported as being due to COVID-19 extremely difficult to interpret.
John M Wheeldon I get your point. I too believe that major changes in the demographics of many countries will take place and we we will be able to assess the outcomes of this epidemic some time in the future.
Salvatore Vicidomini Thank you for the informative points. Is the virulence of virus in Lombardia already determined or is it a theory? Why do you think a second coronavirus emerged from the Middle East? This is conflicting with the eating (pigs) and hygienic habits (Muslims) of most people living there.
Rajkumar Rajendram Yes sure, the role of politics and diagnostic flaws can not be overlooked.
This is a hypothesis only of occurrence of a second pathogens in N. Italy, (a second diverse virus; a hospital resistant bacteria; but also a second Coronavirus as MERS or HKU1 ...) In the past decade it was record MERS in Italy and MERS is not of Middle East but it is (as SARS-CoV viruses) an east-asiatic virus with a restricted area because of its huge mortality (low potential distribution across the world, as for ebola virus).
According to the impressive and increasing mortality in Lombardia, all the hypothesis would be considered by Italian Gov. but there is not attention in my country for this tragedy :(
Technical Report 2019nCoV or SARS-CoV/2 Coronavirus {Riboviria Nidovirales Co...
Have a nice week Najla Saeed Dar-Odeh and thank your for reply.
--sv--
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2 Recommendations
John M Wheeldon
Retired ex-EPRI
https://www.researchgate.net/profile/Najla_Dar-Odeh
Stephen I. Ternyik
I think the tone of my post was a little pessimistic but there is reason for optimism in the fight to combat the virus.
https://www.theguardian.com/world/2020/mar/28/coronavirus-vaccine-when-will-it-be-ready
Research bodies have a head start as they have anticipated that the next pandemic would be flu-related and have been working on “prototype” pathogens. This information plus the fact that the Chinese have shared the genetic sequence of the virus gives cause for optimism, at least to this non-medical researcher.
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Najla Saeed Dar-Odeh
University of Jordan
Salvatore Vicidomini we all need to keep our hopes high and work together to fight this virus.
As you said John M Wheeldon let's be optimistic, to get a vaccine or to get rid of this virus completely.
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Rajkumar Rajendram
King Saud bin Abdulaziz University for Health Sciences
The availability of healthcare in general and specifically critical care will affect case fatality. In China and Italy where large numbers of healthcare professionals were infected the capacity to deliver healthcare was substantially reduced.
Another important factor to consider when trying to interpret variation in mortality rates between countries is differences in cultural interpretation of quality of life. This impacts the social and medical ethics and the delivery, limitation and withdrawal of life sustaining therapies.
In many Western cultures quality of life is valued far more than quantity of life. In those setting limitation and even withdrawal of life sustaining therapies are a common mode of death.
In many Eastern cultures quantity of life is valued more than quality of life. In these settings treatment limitations and withdrawals of therapy are rare. Admission to intensive therapy units and prolonged organ support are common. Mode of death is often cardiac arrest.
These differences are magnified when there are limited resources particularly in Western countries. The social and medical acceptance of treatment limitations is increased; this may significantly increase case fatality rates.
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Alaa Allahham
University of Freiburg
Despite the fact that actual numbers are much higher than the announced, I believe, in my personal opinion, that also our diet plays a key role in this variation among countries. Besides affecting the efficiency of the immune system, our diet significantly affects the cell membrane composition which plays an important role in virus infection.
There are many other reasons such as climate, screening methods, level of healthcare, cultural and social habits, etc.
Also, the sensitivity and the numbers of available tests per day are quite different among countries. In some countries, people with minor symptoms have access to take the test, while in other countries a fair number of people get infected, showing mild, minor, or no symptoms, recover without being tested.
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Najla Saeed Dar-Odeh
University of Jordan
Thank you Alaa Allahham for all the points that you mentioned. There are all valid.
I learnt also from one of my mentors Asem Shehabi that the relatively low number of infected cases in some countries may be explained by their implementation of BCG vaccine. This vaccine is being used now in Australia among healthcare workers.
https://www1.racgp.org.au/newsgp/clinical/healthcare-workers-to-trial-tuberculosis-vaccine-f
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Asem Shehabi
University of Jordan
Salamat,
The incidence and mortality numbers due to Coronavirus infection is clearly less among all Arab countries and India and many African countries who have used BCG vaccine, compared to America and most European countrIes.BCG is known to induce cellular immunity which can help to control certain bacterial and Candida lung infection.
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1 Recommendation
John M Wheeldon
Retired ex-EPRI
In the UK, and possibly other European nations, the use of face masks is not recommended as a means of preventing individuals from being infected by a virus. They are ill-fitting, require regular adjustment, and result in wearers touching their faces and possibly transferring the virus from their hands. Further, they quickly become moist, creating a Petri dish to culture your own personal batch of germs. The general view is that they offer little protection, create a false sense of security, and promote anxiety in those not wearing masks.
An observation made in the press today is that nations in which wearing face masks is more prevalent, the coronavirus infections are lower: China, Hong Kong, Japan, Singapore, and South Korea. China is also included as their number of infections is exceeded by non-face-mask-wearing nations: Italy, Spain, USA and maybe UK.
The reason for the effectiveness of the face mask (if indeed the view is correct) is that it prevents those infected from infecting others by suppressing the transmission of droplets that if ingested by others will transfer the virus.
An observation at present that may be substantiated after the coronavirus pandemic is brought under control.
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Najla Saeed Dar-Odeh
University of Jordan
This is absolutely true. Face masks do not provide complete coverage. There should be other means to cover the susceptible areas of the face. Safe distance may be a better protective means.
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John M Wheeldon
Retired ex-EPRI
https://www.researchgate.net/profile/Najla_Dar-Odeh
The role of face masks (not respirators) and their efficacy will be established in due course. For the present, social distancing is certainly a primary method of control and people with the virus should not be out and about but self-isolating rather than trying to contain their infection with a face mask. The truth will out but meanwhile, stay safe and healthy..
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John M Wheeldon
Retired ex-EPRI
I am not an epidemiologist but I am, as everyone else must surely be, interested in when the coronavirus infections will peak. In the UK some estimate around April 12 others somewhat later. In common with every field of study, five experts will provide five or more opinions. So as a non-expert I have looked at the coronavirus data presented at this link
https://www.worldometers.info/coronavirus/#countries
The data, of course, can be looked at in multiple ways but the only way I could identify that indicated when the peak might occur was as follows. Other approaches either had too much scatter or were more suited to determining when the peak had occurred rather when it might. The data are presented in active-graph form so extracting the data is rather slow, so in addition to the UK I looked at the high infection countries, China, Italy, Spain, USA, and the world. Before proceeding, this analysis is only superficial as I do not have the background to make adjustments based on experience.
The approach used was to determine the daily infection increase compared to the previous day plotted against the day since the infection was first reported When this ratio falls below one it indicates that the infection rate is falling. I chose to use the active infection data, which is the total infection minus those who recovered and those who did not. The graphs also show the lockdown date and the projected peak in infection.
China: the data were well fitted to an inverse power law and this form of relationship was selected to fit the data for the other countries. The lockdown occurred on Day 14 of the infection and the peak was reached on Day 40, 26 days later.
Italy: the infection is declining at a similar rate to that of China. The lockdown occurred on Day 40 of the infection and the peak is projected for Day 70, 30 days later, on April 7. Three days ago, Italy extended the lockdown to April 12.
Spain: the infection is declining at a similar rate to that of China and Italy. The lockdown occurred on Day 47 of the infection and the peak is projected for Day 77, 30 days later, on April 15. Three days ago, Spain extended the lockdown to April 11.
UK: the infection is declining at a slower rate than that of the other three countries (CIS). The lockdown occurred on Day 54 of the infection and the peak is projected for Day 85, 31 days later, on April 23. The UK government is preparing the country for a continuation of the lockdown.
USA: the infection is also declining at a lower rate than that of the other three countries (CIS) but more rapidly than the UK. The lockdown occurred on Day 57 of the infection and the peak is many weeks off, possibly as much as 50-60 days, which is the end of May. This may be why up to 200,000 deaths are projected
World: Three graphs resulted from his analysis.
Using all the data supplied for the world resulted in a “bath-tub” shaped curve. This shape arose because as the infections declined in China they started to rise in the rest of the world.
The second graph is for the world’s data minus that of China. Still a bit of a bath tube so based just on observation, I decided to fit the power law to just the last 40 days of data. This has the lowest rate of decline in infections, but the tail-end of the data looks similar to that of the USA so I decided to remove the USA data.
The third graph is for the world’s data minus that of China and the USA. Because of scatter in the first few data points, based just on observation, I decided to fit the power law to just the last 30 days of data. This has a similar rate of decline in infections to the USA, but the peak is projected to occur after around 110 days well before that projected for the USA
So perhaps in Europe and around the world peak infection will have occurred by the beginning of May but the USA will have to wait until the end of May. The peak is one thing, ensuring that the infections do not pick up again after that is another.
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Najla Saeed Dar-Odeh
University of Jordan
Thank you for your explanation John M Wheeldon . The figures that you used for your predictions are the official numbers. Bur are we sure that these reflect the reality?
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John M Wheeldon
Retired ex-EPRI
https://www.researchgate.net/profile/Najla_Dar-Odeh
“Ay, there’s the rub.” I think your question plays to posts earlier in this thread; complete understanding will not materialise until well after this scourge is over and all the data are collected and validated. From tragedies around the world, I think experience shows that things are worse than official figures indicate. How much worse in this case I do not know, and can only hope that the figures are indicative of the true trend in the virus’s progress.
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Serge F Fourcand
Independent Researcher
In my opinion, there are two factors involved:
First, there is a discussion on the correlation of high Covid-19 mortality and the R1b haplogroup on another thread on Research Gate. Based solely on graphically correlating the geographical distribution of the Covid-19 pandemic in Europe, the particular branch of R1b affected is the R1b S28 haplogroup. This is the Italo-Celtic branch.
The web link to the map of the R1b haplogroup subset that best matches the pandemic in Europe is below:
https://www.bing.com/images/search?view=detailV2&id=4C6614847D85D3B0D6CC66B64D19013B29759565&thid=OIP.puD16agUD5jQw4AAlA9EbwHaFH&mediaurl=http%3A%2F%2Fadamsfamilydna.com%2Fwp-content%2Fuploads%2F2013%2F04%2FHaplogroup-R1b-S28.gif&exph=552&expw=800&q=R1b-S28&selectedindex=0&ajaxhist=0&vt=0&eim=1&ccid=puD16agU&simid=608018707051842684
A link to a map of the distribution of the pandemic in Europe as 4/23/2020 is below:
https://www.bing.com/images/search?view=detailV2&id=4C6614847D85D3B0D6CC66B64D19013B29759565&thid=OIP.puD16agUD5jQw4AAlA9EbwHaFH&mediaurl=http%3A%2F%2Fadamsfamilydna.com%2Fwp-content%2Fuploads%2F2013%2F04%2FHaplogroup-R1b-S28.gif&exph=552&expw=800&q=R1b-S28&selectedindex=0&ajaxhist=0&vt=0&eim=1&ccid=puD16agU&simid=608018707051842684
This would also explain the magnitude of the pandemic in the New York area.
Second, I believe that intubation has been overused in some countries such as the United States because it is a convenient way for the hospitals to prepare for possible emergencies during procedures involving anesthesia. I, personally, have been intubed for medical procedures that did not really mandate it since I did not have any respiratory path blockage.
I do not believe that intubation should be necessarily the first resort when a patient shows up with advanced corona virus symptoms. From informal conversations, it would appear that Canada, for example, uses ventilation more with masks and mouth pieces, and may appear to have a lower mortality rate per admitted patients.
Effectively, the existing hospital practices in the U.S. may have been somewhat responsible for the high mortality rate among admitted patients in the United States, particularly when considering that many of them were done during high stress situations. It is also proven that there is a high mortality rate among older patients when intubation was used, even before the Covid-19 pandemic.
Best regards
Serge F. Fourcand
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Serge F Fourcand
Independent Researcher
To add to the points that I made in my previous reply, a report just came out indicating that 88% of the Covid-19 patients that were intubed in New York have died.
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Asem Shehabi
University of Jordan
As I know intubation of patients is highly associated with bacterial multidrug resistance infection and may be this is feature has contributed to high mortality?
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Abdelaziz Touati
Université de Béjaïa
It's difficult tu give une answer or one explanation. Perhaps population genetic, population age, environmental conditions, understimated number of covid19,...
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Asem Shehabi
University of Jordan
Dear Prof. Abdelaziz,
Ramadan Mubarak
I will report soon why most Arabic countries and other developing countries have few cases of severe infection and mortality due to covid-19.
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Najla Saeed Dar-Odeh
University of Jordan
Looking forward to your report Prof Asem
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Najla Saeed Dar-Odeh
University of Jordan
Serge F Fourcand The association with R1b haplogroup is an interesting theory thinking of the different diseases (Junstinianic plague, Antonine plague, Black death) that affected the Roman Empire throughout history.
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Najla Saeed Dar-Odeh
University of Jordan
Abdelaziz Touati I think that all of what you mentioned applies. Efforts are intensifying to find treatment and vaccine but the virus may just vanish and become just a memory!!
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Abdelaziz Touati
Université de Béjaïa
How about MERS-CoV? Why this virus is mainly disseminated in the KSA? Perhaps by answering these questions, we could answer the question of why we don't have the same rate of death in different countries with the SRAS-CoV2.
Besides, I am convinced that there are many entangled factors which could change per country. The virus is normally influenced by many conditions such as temperature, humidity, drought, population density, hygiene education, quality of life, nutrition quality, immunity, age median of the population, international trade, ..etc
For this reason, I think that we should learn about this pandemic to be better prepared for the next wave of other viruses...
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Najla Saeed Dar-Odeh
University of Jordan
MERS-CoV was transmitted from camels which explains its geographic distribution. But we don’t hear of this virus any more
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Serge F Fourcand
Independent Researcher
I would like to recommend the article below as relevant to our discussion:
The article by Linguist Prof. Ángel Gómez Moreno (Universidad Complutense de Madrid), "Coronavirus, Population Genetics, and Humanities", Mirabilia, 30 (2020, 1): Special Issue: https://www.revistamirabilia.com/sites/default/files/pdfs/01._gomezmoreno.pdf
Best regards
Serge
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Vicent Martines
University of Alicante
I think it is right an avenue of knowledge worth exploring, from the work by Prof. Gómez Moreno (Ángel Gómez Moreno (Universidad Complutense de Madrid), "Coronavirus, Population Genetics, and Humanities", Mirabilia, 30 (2020, 1): Special Issue: https://www.revistamirabilia.com/sites/default/files/pdfs/01._gomezmoreno.pdf ).
But, I think we need the contributions from a wide shared knowledge from lots of disciplines.
A world wide pandemic needs earn solutions from a world wide knowledge contributions.
Do you know, my colleagues, about any more works in this same or similar approach?
My so many thanks / Xucrén
Vicent
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Serge F Fourcand
Independent Researcher
The analysis of the spread of Covid-19 and possible treatment can be best understood by assuming that this particular instance of the corona virus includes elements of HIV and also, possibly, some Ebola genetic traits. With respect to the latter, there appears to be a geo-correlation between the regions affected by Ebola and the footprint of Covid-19 in Africa. This could be circumstantial and I have not yet looked at it in any depth.
By any means, do not assume that Covid-19 is single-faceted.
Finally, without wanting to hurt anyone’s feelings, we have a responsibility to be honest about it: the virus did not originate in Wuhan’s wet market.
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Najla Saeed Dar-Odeh
University of Jordan
The more answers I get, the more questions I have!. Serge F Fourcand what do you mean?
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Serge F Fourcand
Independent Researcher
I guess that you are trying to make me live up to my previous words
I will try to make a long story as short as possible.
President Trump indicated yesterday that he had seen evidence that the Covid-19 virus came from a Chinese lab in Wuhan. For a change, he was not lying.
Early in February 2020, I was alerted by someone of the following press release from the United States Department of Justice:
https://www.justice.gov/opa/pr/harvard-university-professor-and-two-chinese-nationals-charged-three-separate-china-related
Three principals were identified in the release from the United States Department of Justice: Dr. Charles Lieber, Yanqing Ye, and Zaosong Zheng.
Who are they and why were they joined together in this communiqué?
Dr. Charles Lieber, as indicated in the above release, was the Chair of the Department of Chemistry and Chemical Biology at Harvard University, the Principal Investigator of the Lieber Research Group at Harvard University, which specialized in the area of nanoscience, and the recipient of more than $15,000,000 in grant funding from the National Institutes of Health (NIH) and Department of Defense (DOD).
As put forward in the communiqué, Dr. Lieber was also an employee of the Wuhan University of Technology since about 2012.
Yanqing Ye is a graduate of the National University of Defense Technology (NUDT). The National University of Defense Technology (NUDT) was founded in 1953 as the People’s Liberation Army (PLA) Military Academy of Engineering. She is now a Lieutenant of the People’s Liberation Army (PLA).
Zaosong Zheng is the third person mentioned in the release from the United States Department of Justice.
Coincidentally enough, he is associated with Sun Yat-sen University in Guangzhou, Guangdong, China. One may remember that SARS began in Guangdong Province, China. Of course, this is only circumstantial. Guangzhou is a major city and should be expected to have a first-class university.
Zaosong Zheng made bail in early March and is supposedly on house arrest in Massachusetts.
So, if all what was mentioned above is circumstantial and does not prove a connection between the three individuals listed in the release and the corona virus, why were they grouped together in the communiqué of the United States Department of Justice? Because of another reason? Which one?
I finally received confirmation a few days ago, actually before President Trump’s announcement, that the Covid-19 virus had been genetically modified in a lab in Wuhan. While I can not name the source, the informant’s veracity cannot be questioned. The same informant also indicated that the first person publicly known person to die in the U.S. from Covid-19, Patricia Dowd, from Santa Clara, an employee of Lam Research, was infected via a co-worker from Lam Research’s Wuhan office. This co-worker contracted the Covid-19 virus while standing in line at a nearby pharmacy in Wuhan while waiting to buy a mask during the outbreak in Wuhan.
I will not speculate in writing about the intentions behind the genetic manipulations that took place in the lab in Wuhan. Nor will I speculate on whether the SARS pandemic, which started in Guangzhou, Guangdong, China, was a case of accidental transmission from animal to human.
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Najla Saeed Dar-Odeh
University of Jordan
Thank you Serge F Fourcand for taking the time and effort to write down your thoughts. I am trying to absorb the data mentioned in your post; for me this looks like one of Hollywood movies which I am not one of their fans. One should be hopeful that if this is actually a lab-made virus, it should come with a lab-made vaccine or treatment !!
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Chris Golightly
GO-ELS Ltd
It is quite possible that the supposed links between the three individuals Dr. Charles Lieber, Yanqing Ye and Zaosong Zheng is entirely false and simply not related: https://www.snopes.com/fact-check/charles-lieber-arrested-coronavirus/ .
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Najla Saeed Dar-Odeh
University of Jordan
Chris Golightly Thank you for your contribution. While political issues may overlap with the scientific truth, we may not be able to fairly judge the situation. "Tomorrow, snow will melt down, and what lies beneath will appear!" I am still looking for answers to my original question. I even added another question about research conducted mainly in Arabic countries about COVID-19, but no answers are received yet . Unfortunately, I feel that Arabs are just observers. Where are the clinical studies that describe patients and disease outcomes?? Especially from countries that have thousands of cases and a rising toll of deaths?
Where are the infectious disease people? Where are the respiratory disease people? You are all excused if the reason is lack of time due to taking care of your patients!
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Chris Golightly
GO-ELS Ltd
I highly recommend the paper by Prof. Gómez Moreno mentioned above. In addition, the following may assists in an understanding of the fact that there is clearly a genetic component involved here, almost certainly related to Haplogroup R1b: Useful charts. John Burn-Murdoch FT: twitter.com/jburnmurdoch
Haplogeography of COVID-19: A Hypothesis”,March 2020. DOI: 10.13140/RG.2.2.17496.44803
www.researchgate.net/publication/340428670_Haplogeography_of_COVID-19_A_hypothesis
John Hopkins – COVID Mortality: coronavirus.jhu.edu/data/mortality
Scientific American (2020), “Do Your Genes Predispose You to COVID-19?
www.scientificamerican.com/article/do-your-genes-predispose-you-to-covid-19/
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Serge F Fourcand
Independent Researcher
Hi
Some of you may be interested in the following article:
Texas A&M Researchers To Lead Testing Of Tuberculosis Vaccine To Fight COVID-19
Countries that have extensive BCG vaccination programs appear to fare better during this pandemic.
Best regards
Serge
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Serge F Fourcand
Independent Researcher
https://today.tamu.edu/2020/04/29/texas-am-researchers-to-lead-testing-of-tuberculosis-vaccine-to-fight-covid-19/
The URL is above
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Najla Saeed Dar-Odeh
University of Jordan
Serge F Fourcand
Chris Golightly
Many thanks for your answers, I believe they are useful reads for all those interested!
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Frank Wallace Bentrem
Commonwealth Computer Research Inc (CCRi)
It may be a matter of genetics:
Preprint COVID-19 Death Rate: Is it in our DNA?
Similar to the paper mentioned by Vicent Martines
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Vicent Martines
University of Alicante
Very interesting paper, both in method as in data.
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Najla Saeed Dar-Odeh
University of Jordan
Frank Wallace Bentrem A concise and informative paper! Many thanks to you and your daughter.
I am now curious about the genetics in the Arabic region which showed low death rate. A different and protective haplogroup?
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Frank Wallace Bentrem
Commonwealth Computer Research Inc (CCRi)
Indeed many Arabic countries show very low death rates, e.g. Oman and Saudi Arabia. However Kuwait and UAE are in line with the prediction from R1b haplogroup predictions. I have speculated that there is a percolation threshold around 3% R1b below which death rates remain very low.
You may be interested in a preprint by Gigi Tevzadze who discusses the possibility of a protective haplogroup. Preprint Haplogeography of COVID-19: A hypothesis
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2 Recommendations
Najla Saeed Dar-Odeh
University of Jordan
Another interesting paper
Thanks Frank Wallace Bentrem
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Najla Saeed Dar-Odeh
University of Jordan
Dear Frank Wallace Bentrem Is your paper citable?
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Frank Wallace Bentrem
Commonwealth Computer Research Inc (CCRi)
Yes
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1 Recommendation
Dariusz Prokopowicz
Cardinal Stefan Wyszynski University in Warsaw
The above question was asked in March 2020, i.e. at the time when the 1st wave of the SARS-CoV-2 (Covid-19) coronavirus pandemic began and the World Health Organization announced the state of a global epidemic, i.e. pandemic. Since then, many research teams have been established around the world that have conducted and are still conducting research on various aspects of both the SARS-CoV-2 coronavirus, the Covid-19 disease caused, the determinants of pandemic development, the improvement of anti-pandemic security instruments, etc. We already know many different factors determining the different level of pandemic development in individual countries.
Best wishes,
Dariusz Prokopowicz
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2 Recommendations
Najla Saeed Dar-Odeh
University of Jordan
Yes indeed Dariusz Prokopowicz . The first wave was very mild in some countries such as Jordan for example. Now, the second wave is fierce. We may witness the spread of herd immunity before vaccination is fully accomplished!
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References
- Marone G, Granata F, Spadaro G, Genovese A, Triggiani M. The histamine-cytokine network in allergic inflammation. J Allergy Clin Immunol. 2003;112(4 Suppl):S83–S88. doi:10.1016/s0091-6749(03)01881-5
- Yan-Rong Guo, Qing-Dong Cao, Zhong-Si Hong, Yuan-Yang Tan, Shou-Deng Chen, Hong-Jun Jin, Kai-Sen Tan, De-Yun Wang, and Yan Yan The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak – an update on the status. Mil Med Res. 2020; 7: 11.
- Zheng, H., Zhang, M., Yang, C. et al. Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients. Cell Mol Immunol (2020). https://doi.org/10.1038
- Front. Pediatr., 14 November 2019 | https://doi.org/10.3389/fped.2019.00431). /s41423-020-0401-3).
- J A Carr, J Rogerson, M J Mulqueen, N A Roberts, and R F Booth. Interleukin-12 exhibits potent antiviral activity in experimental herpesvirus infections. J Virol. 1997 Oct; 71(10): 7799–7803.
- Jorge Alberto Acevedo-Murillo, Miguel Leonardo García León, Verónica Firo-Reyes, Jorge Luis Santiago-Cordova, Alejandra Pamela Gonzalez-Rodriguez2 and Rosa María Wong-Chew, Zinc Supplementation Promotes a Th1 Response and Improves Clinical Symptoms in Fewer Hours in Children With Pneumonia Younger Than 5 Years Old. A Randomized Controlled Clinical Trial. Front. Pediatr., 14 November 2019 | https://doi.org/10.3389/fped.2019.00431
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