I understand there are a number of malignant and benign causes of persistent general lymphadenopathy which affects the axilla and cervical lymph nodes (including the supraclavicular) and present with type B symptoms (night sweats, fatigue, urticaria, nausea, etc.). Research also shows that enlargement of the supraclavicular lymph node is more suggestive of malignancy (~ 90% in those >40 yrs). However, it appears from the research that lymph node T cell proliferate disorders are difficult to distinguish from T cell lymphoma. There is some research that state that T cell proliferation ( 50-90%) within lymph nodes, combined with elevated CD4:CD8 ratio (>4), double positive or negative CD4 & CD8, and either absent or dim expression of T-pan antigens CD2, CD3, CD5 and CD7 all strongly indicate T cell lymphoma. Are there any benign disease that have similar findings and how does one make a correct diagnosis?
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