I have no referencies at this moment but is clear to me, at a first glance, that there must be differences because of their structural disimilarity considering same size distribution. The layers multiplicity of the multilamellar version affect its cargo capacity and its disassembling process must be impact the delivery rate. I think you must consider this and the following comments for our colleages. Have a nice day.

I am not sure what you mean by delivery efficiency.

If you are talking about loading capacity, this value is higher for unilamellar liposomes. Obviously, unilammelar liposomes provide more internal volume and thus accomodate more cargo than the same amount of lipids organized in multilamellar liposomes.

If you mean delivery at the scale of the whole body, multilamellar liposomes are less efficient upon iv administration since they are cleared more rapidly by RES.

If, as you further specify it, you mean cargo release (which is different from delivery), than there should be differences indeed. But they are difficult to estimate taken that the initial loading capacity is different.

Hi,

SUVs are more efficient in terms of encapsulation of hydrophilic molecules due to increased internal aquouse volume, however, MLVs having higher lipid content are capable of encapsulating higher amount of hydrophobic molecules. If it is possible to obtain both SUVs and MLVs with a size below 200 nm, you should consider the hydrohilic/ hydrophobic characterof entrapped molecule of whim.

Once again comparing SUVs and MLVs of the same size, delivery is more about the size and surface properties of the liposomes rather than the lamelarity, but, release capacity is directly related to the lamelarity where the more the number of layers, the slower the release. For SUVs, once the liposome membrane disturbed, it releases its content, however, in the case of multilayered systems, the release mechanism follows a multistep release, in each layer only a part of the liposomal content can be released. I hope this will be helpful.

Thank you all for your valuable answers! I really appreciate it!

Gracias! Спасибо! धन्यवाद! Teşekkürler!

If you had 100nm liposomes of which were ULV or MLV, the former would have a significantly higher hydrophilic loading capacity. As Rukan said, MLV = increased lipid content = higher hydrophobic loading capacity. As a result, MLV seem to retain hydrophobic molecules for longer (slower release) however this depends on the nature & extent of disruption.

You must also consider chain length, head group properties & bilayer packing, more so for ULV systems. I have found MLVs to suppress "leaking" of payloads sometimes seen with ULVs.

Hope this helps!

I think another factor that affecting drug release from the vesicle is the thermodynamic state of the bilayers. Drug release from the solid state bilayers such as the bilayers of DPPC is slower than that from the liquid bilayers such as from PC.