In clinical management of the disease, there is a question of when and to which extent Androgen Deprivation and/or Radiotherapy would make sense. However, I did not find a clear definition especially of high-risk localized prostate cancer.
High-risk, localized prostate cancer is defined this way (according to the EAU guidelines): cT3a or Gleason score 8-10 or prostate-specific antigen > 20 ng/mL.
cT3a is defined by a perforation of the prostate capsule and in this way "locally advanced".
Dear Nici, Is it localized cancer you defined? T3 means capsular perforation and it should be locally advanced Isnt it?
I understand high-risk localized as T1-2 (localized) combined with either Gleason 8-10 or PSA > 20ng/mL. Do you agree?
Thank you both for providing expertise.
I agree with Niels. Hence locally advanced will be high risk will be T3-4 with Gleason 8-10 or PSA > 20.
I used the risk-dependant classification according to the EAU Guideline "Prostate cancer >> Radical prostatectomy ( http://www.uroweb.org/gls/pdf/09_Prostate_Cancer_LR.pdf )
@ Anuruddha: You're right, T3 is locally advanced. That's what i meant in my first posting "cT3a is defined by a perforation of the prostate capsule and in this way "locally advanced"."
This appears to be more complex then though at first sight. Thank you both !!! I think I do understand it by now (:-))).
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