Hi all. I want to know whether large sized vesicles have better encapsulation efficiency or encapsulation efficiency can be higher irrespective of vesicle size. Any reference links will be helpful. Thanks.
No, the size and entrapment efficiency is not having direct connection as such.
Encapsulation efficiency is dependent on what type of molecules you intent to entrap as well as lipid composition, anyway, I confirm no relation between liposome size and encapsulation efficiency.
Entrapment efficiency depends on the kind of active and lipid interaction and lipid composition where as the size depends on lipid composition so one expects the relation between Size and entrapment efficiency along with methodology chosen for the preparation of liposomes but seriously no reports were there showing the direct relationship between two aspects. liposomes of least size range, with acceptable homogeneity index, are reported to entrap more amount of molecule on the other hand MLLV reported to entrap more than ULLV. SO its not so typical to say no relationship between size and entrapment efficiency. Coming to your specific query smaller vesicles have intact structure with fewer possibilities of leakage of entrapped molecules in comparison with larger vesicles but truly it doesn't confines least entrapment of molecules in larger vesicles too.
http://www.ncbi.nlm.nih.gov/pubmed/14690399
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