Since, the primordial Na-pump on the plasma membrane is the ultimate source of energy of animal cells; it appears that the remaining Ca-signaling networks will join the leading Na-pump, and the potential energy is used by remaining networks for homeostasis. Hence, the cellular bioenergetics initiated and managed by the NaAF regulated Na-pump, by turn regulated by the provisional Ca-pump and Ca-signaling, is the leading-center of a cell’s holistic-networks.
We visualized operation of the ion-pump under Ca-signaling as an all-time allosteric dancing of the Na-pump. During operation, the ubiquitous NaAF acts as the dancing-partner cum gate-keeper of the double-gated (two α-subunits) Na-pump allowing simultaneous transport of Na (in) and K (out), while the process is controlled by Ca-signaling. Intensity of the dancing will be affected by the isoform-nature of the Na, K-ATPase which varies in various bodily cells in a tissue-specific manner except brain where the Na-pump is area-specific. The extremely specialized functions of the area-specific brain (of human) are of prime interests now-a-days.
The Ca-signaling is conducted periodically by the provisional Ca-pump which is an altered form of the cell-specific Na-pump. The provisional Ca-pump is entrusted to pump out the excess (inhibitory) local Ca for continuation of Na-pump function for homeostasis, thus making it a stop-and-go type dance.
This brings us to the question we are asking. Are the molecular natures of the provisional Ca-pumps the same as the isoforms of the PMCA well-known in the vast Ca-ATPase literature?
It will be very interesting issue to investigate.
it depends on genetics and disease metabolic dysfunction plays a role in quite a lot of the population.
http://www.sciencedirect.com/science/article/pii/S0005272898001686
I think there is a misunderstanding, Bridget Bengtson. The Ca-pump (PMCA) is wellknown to be present in normal animal cells. however, we found that the PMCA reported in the literature is an altered form of the Na, K-ATPase (Na-pump) which acts as a provisional Ca-pump in high-Ca situation to remove excess Ca from the cell.
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