Dear Riva,

I responded already to your question yesterday.

A primary lung cancer (SCLC or NSCLC) originates in the lung.

NSCLCs can metastases (unfortunately often) to the brain, the liver, et... In this case, it is a metastatic lung cancer and no more a primary lung cancer.

The s.c. LLC model cannot be considered as a metastatic lung cancer.

The s.c. LLC model cannot be considered as a primary lung cancer.

The s.c. LCC model is a "lung tumor model" which does not mimic the clinical situation.

The choice of a model depends on your working hypothesis. Thus, the s.c. LCC model can be a "good model" in some circumstances, and a bad one in other circumstances, as any model. A model remains a model ...

Best regards

Robert

Dear Riva,

Here attached you have three articles about the LLC model.

One article was "already" published in 1974 in the excellent journal Cancer Rwsearch.

A second attachd article shows a nice study using this model and published in PlosOne, which is a good journal.

A third article is a recent review and shows that the LLC model is often use.

There are ~4,000 publications with the LLC model in the PubMed database ...

I would not be too anxious with the LLC model ...

Best regards

Robert

Dear Robert,

Thanks a lot for your help on the subject matter and for useful comments. Really appreciate it!

Best Regards,

Riva Verma