In patients with type 2 diabetes mellitus (T2DM), serum TGF-β1 (Transforming Growth Factor Beta 1) levels are typically elevated. This increase is associated with the development and progression of diabetic nephropathy, as TGF-β1 plays a key role in renal fibrosis and glomerular damage. Elevated TGF-β1 levels can contribute to the pathophysiological changes observed in diabetic kidney disease.

Thank you Mehrab Dashtdar! Can serum TGF-β1 be used as an anti-inflammatory biomarker in clinical test?

Serum TGF-β1 (Transforming Growth Factor Beta 1) has been studied as a potential anti-inflammatory biomarker in various clinical contexts. Here are some key points regarding its use:

1. Role in Inflammation: TGF-β1 is known for its regulatory role in immune responses and inflammation. It can suppress the activation of immune cells, which contributes to its anti-inflammatory properties.

2. Clinical Applications: Elevated levels of TGF-β1 have been associated with chronic inflammation and tissue repair processes. In conditions like autoimmune diseases, its levels may reflect the inflammatory status.

3. Biomarker Potential: Some studies indicate that measuring serum TGF-β1 could provide insights into inflammatory processes in rheumatoid arthritis, systemic lupus erythematosus, and others.

4. Limitations: While it shows promise, the interpretation of TGF-β1 levels can be complex due to its involvement in pro-inflammatory and anti-inflammatory pathways. Levels can also vary based on age, sex, and disease state.

5. Conclusion: TGF-β1 can serve as a biomarker for inflammation, but should be interpreted cautiously and in conjunction with other clinical indicators for accurate assessment.

While TGF-β1 has potential as an anti-inflammatory biomarker, further research and standardization in clinical settings are necessary for its widespread use.

Idon't think so since TGF beta monitoring Fibrosis and cirrhosis in liver , kidney and other tissues ,however long time diabetes joined with subsequent build up of hyperlipidemia may contribute later to renal fibrosis

Thank you Mohamed Elseweidy