Can anybody please provide references on safe use or practice in repetitive transfusions of fresh (frozen plasma)? What are the cases where such procedures are most often used?
Tnx!
multiple transfusion of FFP is safe provided you transfuse group matched or compatible
Dear Urban, I hope these links are related to your inquiries.
- Problems and errors associated with transfusion:
http://www.psanes.org/LinkClick.aspx?fileticket=ZP5Boc64uCI=
- Use of fresh frozen plasma:
http://www.transfusion.com.au/blood_products/components/plasma/use
- Also Fresh Frozen Plasma: Indications and Risks
https://consensus.nih.gov/1984/1984FrozenPlasma045html.htm
Kind regards
Faisal
It depends on what is your definition of safe. There is an inverse correlation between FFP transfusion and morbidity post surgery. If you use FFP from female donors who had several pregnancies there is an increased risk for TRALI. Infusion of FFP will result in transfusion of relative high amounts of citrate which may partially anticoagulate the patient and can cause decreased cardiac contractility due to Ca chelation
Thank you all for your answers! There are very few reports regarding multiple/repetitive transfusions of plasma, namely over longer time periods. If anyone has a reference or experience in this matter, it would be very welcome.
Tnx!
If you use SD poolplasma (OctaplasLG) from the same Lot number, your first unit will be exact the same as your last unit.
Hi Urban
Regarding references, I suggest that you have a look at some of the older haemophilia literature, i.e. before the time when fractionated coagulation factor products became widely used for patients with chronic coagulopathies.
These days FFP is rarely used for patients with chronic conditions that require longer-term repetitive transfusion for coagulation deficiencies. Instead, specific fractionated or recombinant coagulation factors are used or perhaps cryoprecipitate. FFP is typically used for situations of acute bleeding or risk of bleeding, such as prior to surgery in high risk patients.
Hope this helps.
Regards, Rosemary
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