If we compare Insulin/C Peptide and ghrelin/obestatin, then preproghrelin could be found in the circulation. I nether saw any publication or indication of this.
Does anyone have indication or data related to the potential presence of circulating proghrelin, and in which model this has been seen?
Preproghrelin is cleaved to yield proghrelin which is then acylated by ghrelin O-acyltransferase to yield octanoyl ghrelin and decanoyl ghrelin. Only octanoyl ghrelin is able to bind and activate the GHS-R1a receptor. Unacylated ghrelin (des-acyl ghrelin) is also present in plasma but its function is controversial.
References
Christine Delporte, “Structure and Physiological Actions of Ghrelin,” Scientifica, vol. 2013, Article ID 518909, 25 pages, 2013. doi:10.1155/2013/518909
Dear Entedhar,
Thank you for your answer, however this is not related to pre (pro)ghrelin but to ghrelin.
We have a good experience/knowledge on this marker.
Sincerely
Please go through the article:
https://www.researchgate.net/publication/336340496_Obestatin_in_male_reproduction_and_infertility?_sg=h7iSX2pxCRhw7ffg6aCWJdGBnn0J3QhojLEEp5SJZNRV-XYByOLL1xNfedFcnQGq1VLYoU9TdNPRji04FX0rLnETs6RfNLLJMizWKpOH.b2qxDs63wrUzFO6-Q3kwlMZrX034W9aYs300o1nIOvF3-AgDKWLxfip16kUkLWYIegeyYEXtG04-YVNNbwFfgg
Entedhar Sarhat Unacylated ghrelin (des-acyl ghrelin) is also present in plasma but its function is controversial. How about now? Is it still controversial?
Dear Patrick Vitaux . See the following useful RG links: Article Combination of Selective Immunoassays and Mass Spectrometry ...
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/obestatin
https://academic.oup.com/jcem/article/92/5/1875/2598830
Article Serum obestatin level strongly correlates with lipoprotein s...
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