Hi Connie, I am not an expert on Parkinson's (I believe there is a forum on RG for Parkinson that you can post questions to experts).

I do know a little bit about blood physiology and chemistry. In general, ingested metal ions and nanoparticles will not make it to the brain via blood. The first barrier is the intestinal cells that take up certain components from food. Toxins (eg heavy metals but not big particles) can pass through these cells though.

The liver and kidneys are then the gatekeepers that get rid of toxic materials in blood. They also bear the brunt of accidental and intentional poisoning.

The brain is also protected by the blood brain barrier (BBB), which is very selective in what is let through to the brain from blood. I hope this helps.

Thanks. The latest news is about leaky blood brain barrier.

Hi, I would be interested in that research because I have studied endothelial cells. Can you provide links? Thanks!

Hi Cinnie,

please go with this link, it will help you to find out the correlation between nanoparticles and Parkinson..

http://dx.doi.org/10.1016/j.ijpharm.2011.05.062.

My own research has shown that occupational exposure to heavy metals is associated with a younger age at onset of Parkinson's disease. 

http://www.ncbi.nlm.nih.gov/pubmed/26109889

I also have a website where you can learn more about the relationships between neurotoxicants exposure, genetics and age at onset of Parkinson's disease.

http://www.neurotoxicants.com/

The Fenton reaction is implicated in iron toxicity.

Iron is deposited with manganese in the globus pallidus due to an up regulation of the divalent metal ion transporter (DMT-1).  Michael Aschner has done extensive work looking at this relationship.

http://toxsci.oxfordjournals.org/content/92/2/516.full.pdf

Yes.  Below is a link to article regarding trichloroethylene's involvement in inducing Parkinsonian symptoms.  It's a common degreaser and environmental contaminant.

http://www.ncbi.nlm.nih.gov/pubmed/19922440

Copper and Iron works together similar to calcium and magnesium (60:40 ratio).

Calcium cancels iron.

Where there is copper, there is iron.

Unabsorvable calcium can affect the body is not disposed or detoxified. Same with iron or copper.

More at www.clubalthea.com

The relationship between hemochromatosis and risk for developing PD has also been evaluated with conflicting results.   I am not sure if any of these studies have specifically looked at age at onset of PD to see if iron was a disease progression modifying factor in those patients who are comorbid for both but in my opinion this would be a pragmatic approach to investigating the relationship.