The most used definition for "Neoplasia" was put forth by Willis RA in 1952 based upon the understanding of the disease process of that era. Since then our understanding of neoplastic process has increased so much.
1. Do you think even after 60 years, the definition is still valid or needs modification? For eg., the hall mark features of cancer proposed by Douglas Hanahan and Robert Weinberg in 2000 conveys much better fundamentals than old definition.
2. If so, has any agency such as IARC has taken steps to define an universally acceptable definition that encompass all current knowledge of the process ?
3. Do you think this exercise is a waste of time and we need to focus efforts for more in depth understanding of the disease than on defining the disease?
Hi， I just want to learn what issues are caused by the word "neoplasia"?
I see no issues with use of the term "Neoplasia" or "tumor" or "cancer" but the universal definition of the term; and the meaning that it conveys or describes by and large as implied by Prof. Willis. Perhaps, in my opinion, we got to expand the spectrum of meaning that the term "Neoplasia" implies by adding to Prof. Willis definition of tumor or neoplasia.
Rooban your question can be interesting, I think, if we consider the implication of psicosomatic and intoxication meaning related. The official medicine needs urgently to open the mind and the "heart" to natural medicine, as you know surely ayurvedic, chinese, tibetan and naturopatic tradition consider also the olistic aspect of the man. The name "neoplasia" simply I think indicates the birth of a new type of cells, that don't have the function for which they are thought. These topics should be considered to improve in a significative way the regression of disease: a big and continous situation of stress seen as not resolvable in loliness (Richard Hamer and stress theory) generates a lot of free radicals, as in the same way make low quality food (industrial, not organic, vegetal oils old or refined), pollution in environment, ecc, and intoxicate deeply the tissue and the body. It should considered the action of natural remedies, already found by an empiric and scientific way, to be able to remove these kind of compounds from the body (you can search the big study and experience of french and belgium people as Bergeret, Tetau and Pol Henry). Also by a somatic aspect we can see the cancer as the last chance to change otherwise the die will arrive certainly. You can search also for REACH european project, start for try to lower of 10% the die for cancer, by monitoring and regulate the chemical substance used in the most common object used each day (from varnish, additivs included in food and sweet pies, plastic object and so on..). I hope the reasercher and medic people start to consider all the way to avoid pollution in food, water, cosmetic, clothes, toy, and objects, coordinate a work with politics for example, all the way to strenght the body and immunity sistem, to inhibit enzyme of neoplastic tissue, responsible of its development and survival, and a way to remove the toxic compound taken by pollution in its different provenience. As you should know a chemical substance sintetized by laboratory can't act without leave some substances in charge of detoxification body system (colon, liver and so on...), and it can't be used more of 3 chemioterapic (the only exception is CHOP protocol used for non hodgkin lymphoma), because they shall be much toxic combined all togheter, then to apply several strategies which help and strenght the autopotential of the body to found again the healthness, it takes natural remedies. I hope my answer will be useful to you, and to can entry in the new era, since the kali yuga is almost an old word for me....
Yes Friends as the neoplasia is a an extremely complex disease, to find a suitable definition seems to be a herculean task. However, we should look for a broad and short definition , which may encompass most, if not all features of neoplasia.. In this context, 'all those who matter in oncology' should sit together and find a suitable answer.
I think, if we want be sintetic and detailed at the same time, we can define it as "a desease which generate an incontrolled replication of the cells, with a lost of their natural functionality, and an alteration of their metabolism"
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