Is it possible to reconstitute macrophages by adoptive transfer of monocytes after 48-72hrs of injury?

07 July 2017 0 10K Report

Going to deplete macrophages in mice liver by clodronate liposomes (0.1mL/10gm) to check an effect;

1) 48hrs and 72hrs after an injury and then

2) Repopulating the macrophages by adoptive transfer of monocytes (48-72hrs after an injury)

Is it possible that transferred monocytes may differentiate into macrophages at indicated time points? How long intrahepatic clod.liposomes persists once injected. Any opinion regarding this would be appreciated

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