Hi Rajit,  Yes it is, (Danio rerio)  are recognized as an important (some might add even: solid) vertebrate model for human abnormalities in central nervous system development, and genetic screening. The low cost to maintain, the rapid life cycle, optical clarity, and rapid external embryonic development, makes Zebrafish a very attractive animal model, furthermore, recently showing promise in disease models as well.   May I direct you to the listed  below literature, in my opinion,  a good work was done by Swain Ewald, Holly, a Ph.D. Theses titled,   "A zebrafish model of schizophrenia and sickness behavior: MK-801 and endogenous NMDAR antagonism" 2009, University of Louisville, KY. 

Best wishes.

Ghanim

http://www.ncbi.nlm.nih.gov/pubmed/20302822

http://link.springer.com/book/10.1007/978-1-60761-953-6

http://gradworks.umi.com/34/01/3401289.html

Thank you Sir. Your answer was quite valuable.

Dear Rajit,

We know that zebrafish are used as a model for a wide variety of human diseases, including cancer, cardiovascular disorders, angiogenesis, hemophilia, osteoporosis, diseases of muscle, kidney and liver, and, last but not the least, disorders of the central nervous system. In recent years, zebrafish have been used to study neurodegenerative disorders also paving a successful path for translational research.

I'very attached a good review article entitled as: "Zebrafish models for the functional genomics of neurogenetic disorders" that may servery your purpose.