We have screened NTD SCD and we found iron overload in liver. What could be the explanation?
Yes, it's possible depending on the degree of haemolysis, erythropoiesis and hence suppression of hepcidin. It's less common than in non-transfusion dependent thalassaemia, but it can occur. How anaemic is the patient? How high is their EPO? Perhaps measure the hepcidin (still a research test but you could send to a commercial company that does this) and evaluate the hepcidin:ferritin ratio. An alternative explanation could be coinheritence of a hereditary haemochromatosis so I would check for this too.
Dear Sant-Rayn Pasricha Many thanks for your answer The Hb is 9 g/dl Epo not checked but we can do it can you direct me to any commercial company which can measure hepcidin
for HH is another differential which we can look for
and in your practice how many times you saw such cases
Dear @Mohamed, I am at this forum to learn from the feedback of my dear colleagues.
I think if you could exclude transfusional iron overload then the hereditary factor is the possibility
This is very specific question that Sant-Rayn Pasricha has a good answer of it.
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