If your minimal used Polymer have the high self emulsifying property then its possible

To granulate hydrophobic drug powder, consider to use a less hydrophilic polymer solution, such as hydroxypropyl cellulose to improve wettability of the hydrophobic drug. To reduce the agglomeration of the micronized powder, one may use a carrier such as lactose and combine with spray granulation technique.

Wet granulation: PovidoneK 30 solution in water pr ethanol can be used to granulate hydrophobic drug powder, In that case longer mixing time me be needed.

Dry granulation: Mix PovidoneK 30 with drug and granulate by slugging method.