In some way it is the most effective if you compare with GC- MS. GC is used only for volatile compounds  and you can separate almost all organic compounds by LC .

In some way it is the most effective if you compare with GC- MS. GC is used only for volatile compounds  and you can separate almost all organic compounds by LC .

I agree with previous comments. I think LC MS (especially LC  QtoHR MS) was the best method for analysis extract. By this you can know the exact MW of your compounds, than using software of the LCMS, you can predict the molecular formula by isotope pastern (and adduct), and by using data base such as MetFrag, Metlin, Chemspiderm Pubmed etc you can predicts your compounds inside your extracts. For confirmation of course you need standards . Good luck

GC MS and HPLC MS both are good

I am more and more convinced by the larger range of application of SFC. For example in the case of aqueous extract you will have to separate a lot of highly polar compound with logP under 0 and maybe hardly retained in HPLC, whereas they are in SFC.

Many thanks for all your informations, they are very useful. 

HPLC, GCMS by this method almost separation we expect.

Desorption Electrospray Ionization MS (DESI-MS) is better than all others. 

LC-MS is significantly used to analyze large and non-volatile molecules such as complex proteins and peptides. When the material is dissolved in the liquid phase, the liquid chromatography-mass spectrometer can analyze its constituents even with the least volatility or thermal instability, which is difficult to analyze with the GC-MS mass spectrometer gas chromatograph.

Therefore, LC-MS is not suitable for the analysis of essential oils, but LC-MS can be used for analysis of plant extracts.