Recent advances on delivery of anti-TB therapeutics focus on the pulmonary route of administration. Most studies actively target the alveolar macrophages via surface modification of nanoparticles using mannose. Can this strategy be employed for the oral route? If not, then which possible strategy can i explore? Thank you
It is certainly feasible to consider mannose as a targeting method for your nanoparticles. However, it is difficult to say how surface functionalization with mannose will affect your particles for oral administration without further investigation. I would suggest the following review that may be more helpful:
Article Nanotechnology-Based Approach in Tuberculosis Treatment
The oral delivery systems are certainly possible strategies for mannose-based targeting the alveolar macrophages; however, pulmonary routes are more effective than oral routes. Also, the nature of therapeutic agent is so crucial to choose the delivery routes.
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