There is some difference in protocols with regards to evaluation of IGF-1 measurements. Some lab just report IGF-1 and some do it by reporting IGF-1 with IGF-BP3.
While i had some understanding about IGF-BP3 being the carrier proteins or linked proteins with IGF-1 but need some technical advice about the use in combination or isolation testing of IGF-1.
Can someone with related background comment on this?
Most studies did not show an added value for measuring IGFBP-3 in condistions such as acromegaly e.g. Although it is the most important of the IGF-1 binding proteins, it is not the only one and it also binds a lot IGF-II. So getting an idea about free IGF-1 levels is not as straight forward as for other hormones and their corresponding binding proteins. Thats why most studies nowerdays only report IGF-1.
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