I am planning to load liposomes with two different compounds to control the release at different times and environment. Therefore, I am thinking to achieve this by loading my first compound into NPs or micro emulsion and then load them into liposomes. the other compound would be loaded into either compartment of liposomes.
Hi Sarmad.
In principle, what you ask is feasible but I would proceed step by step. At first, try to see whether you can encapsulate the nanoparticles inside the liposomes. This is already a difficult step, as NPs of that size can certainly leak out. Once you optimise the process, see if it is compatible with the drug that you want to encapsulate in the liposomes. Then try to mix all together. It is quite likely that NPs and drug, especially if hydrophobic, can compete each other out.
It is a good idea. However, the phospholipids in the liposomes would be integrated into the microemulsions. The nanoparticles is OK. Please notice the possible problems.
It's not a short and effective way to produce drugs having different periods of escape (see notes above from commentators). you may try to engage different vehicles (microcapsules), liposomes and separate micro/nanoparticles for instance
Thanks Alexey
do you mean to formulate liposomes and nano particles separately and eventually mix them together?
but the question is how you could guarantee they will reach the same place (organ) at the same time. I want to target a specific organ (active targeting) to deliver two compounds but the release is not the same. I want a gab in the time of release of these compounds.
regards
at the same time and having the same concentrations...it is the problem too, indeed. but in your mixed preparation these problems are duty too because of the different distribution rate of the particles of variuos dencity and size. I think the solution exists within a technical sphere. For instance there are techniques for producing liposomes of the same diameter (microfiltration)...
- Badges
- Science topic