Is Infliximab (anti-TNFa) able to cross the blood-brain-barrier?

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Samir Ranjan Panda

Hi Paula Magalhães Gomes

No, it cannot cross BBB. Please find the references attached.

1. "Drug transport across the blood–brain barrier." PMC. NCBI, 2007. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494002/.

2. https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-016-0710-8#:~:text=Due%20to%20its%20large%20size,consequence%20of%20reduced%20peripheral%20inflammation.

3. Brain Abscesses in Crohn's Disease as a Complication of Infliximab Therapy." Cureus. 2020. https://www.cureus.com/articles/58390-brain-abscesses-in-crohns-disease-as-a-complication-of-infliximab-therapy.pdf.

Thanks,

Mick M Welling

Hi Paula, I previously studied radiolabeled antibodies, but these do not pass the BBB. I suggest using llama nanobodies for this purpose. After radiolabeling, you can determine the brain uptake by imaging & biodistribution studies. Good luck.

Mick