Decrease of IL22 levels and increase in Th17 cells correlate with the recovery phase of EAE in rat. This data differs from those already described in mouse EAE, where increased IL22 levels and Th17 cells correlate with peak of disease.
Are observed differences due to IL22 contribution by CD4+ T cells, NK cells or γδ T cells in infiltrating lesions? Are they resulting from differences in epigenetic regulation of effector Th17 cells? Are differences in IL22 associated with the induction of Ahr-dependent Treg cells?
http://PLoS One. 2011;6(11):e27473. doi: 10.1371/journal.pone.0027473. Epub 2011 Nov 7.
We have also to keep in mind that Th22 cells promote also tissue repair. So my question to you will be what were the levels of IL-22 at the others phases(acute phase for exemple). That will help all of us to know whether at this recovery phase, is that IL-22 is consumed? The corralation of IL-17A and IL-22 levels is well established in some autoimme inflammation allthough, the role of IL-17A in EAE is a contreverse in our community(Science I mean).
Best, Kat
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