I read a paper recently,it said "Because differential EZH2 expression was not efficient enough to inhibit production of IFN-γ and TNF-α by CD8+ T
cells, we then investigated the possibility that EZH2 might be
recruited to the promoters of IFN-γ and TNF-α in CD8+ T cells to
induce repressive chromatin states at infg and tnfa loci in CD244+
CD8+ T cells".come from http://www.ncbi.nlm.nih.gov/pubmed/26150504
I cant understand it. If knockdown EZH2 didn't change production of IFN-r and TNF-a. So how can say that recruitment of EZH2 inhibit production of these two cytokine.
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