I am trying to build an electrochemical sensor for detecting a metabolite produced by yeast, through an engineered pathway. I found a protocol for detecting ethanol using alcohol dehydrogenase, in a carbon paste electrode.

I want to know if a carbon paste working electrode is the best available option for detecting other small molecules, using other highly specific enzymes, including enzymes that are not dehydrogenases like alcohol dehydrogenase. What are the most important factors to consider when choosing electrodes for an electrochemical device that will be scaled down to the microfluidics scale?

Thank you for your help,

Nico