Is anybody out there still working on CLEC-1?

More Susanne Sattler's questions See All

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Susanne Sattler

I take that for a 'no'.... that's a shame. Maybe I'll come back to it one day.

Ciara Christianne Lim

Hi Susanne, my Master's dissertation will be something on CLEC-1. Can you tell me which ligands you tested CLEC-1 with, so that I might try a different ligand set? Thanks.

Hi Ciara, saw your message just now! I sent you a private message with my PhD thesis so you can check what we did.

Elise Chiffoleau

Hi, I am working on CLEC-1 and I was reading your post and would like to ask you whether you identified a ligand or in what specific topic you work on CLEC-1 ? best regards

Hi Elise, sorry for the late reply! I'm happy to hear that! I haven't been working on CLEC-1 anymore for a long time. CLEC-1 was part of my PhD project and I was looking for a ligand but couldn't find one. I'm still very curious about it though...

We've published our CLEC-1 data in 2012 (Scand J Immunol. 2012 Mar;75(3):282-92. The human C-type lectin-like receptor CLEC-1 is upregulated by TGF-β and primarily localized in the endoplasmic membrane compartment.) We didn't find a ligand. However our approach was not very systematic, instead we tried whatever we could get our hands on for free. This is what we say in the paper: 'Potential candidates tested were known ligands of other members of the myeloid subfamily of C-type lectin-like receptors (e.g. zymosan, oxLDL and podoplanin), intracellular pathogens (e.g. Toxoplasma gondii and Listeria monocytogenes), ligands of intracellular Toll-like receptors (e.g. the TLR9 ligand CpG) and several primary cell types and cell lines.'

I wish you all the best with your CLEC-1 project!