Dear Zaynab,

Yes. There are, please see the following publications:

1-R E S EAR CH A R TIC L E Open Access

Effects of biosurfactants on the viability and

proliferation of human breast cancer cells

Cristina Duarte1

, Eduardo J Gudiña1

, Cristovao F Lima2 and Ligia R Rodrigues1*

Abstract

Biosurfactants are molecules with surface activity produced by microorganisms that can be used in many biomedical applications. The anti-tumour potential of these molecules is being studied, although results are still scarce and few data are available regarding the mechanisms underlying such activity. In this work, the anti-tumour activity of a surfactin produced by Bacillus subtilis 573 and a glycoprotein (BioEG) produced by Lactobacillus paracasei subsp. paracasei A20 was evaluated. Both biosurfactants were tested against two breast cancer cell lines, T47D and

MDA-MB-231, and a non-tumour fibroblast cell line (MC-3 T3-E1), specifically regarding cell viability and proliferation. Surfactin was found to decrease viability of both breast cancer cell lines studied. A 24 h exposure to 0.05 g l-1 surfactin

led to inhibition of cell proliferation as shown by cell cycle arrest at G1 phase. Similarly, exposure of cells to 0.15 g l-1 BioEG for 48 h decreased cancer cells’ viability, without affecting normal fibroblasts. Moreover, BioEG induced

the cell cycle arrest at G1 for both breast cancer cell lines. The biosurfactant BioEG was shown to be more active than surfactin against the studied breast cancer cells. The results gathered in this work are very promising regarding the biosurfactants potential for breast cancer treatment and encourage further work with the BioEG

glycoprotein.

Keywords: Surfactin lipopeptide; Lactobacillus paracasei glycoprotein; Cell viability; Cell cycle; Breast cancer

2-Potential therapeutic applications of

biosurfactants

Eduardo J. Gudin˜ a1*, Vivek Rangarajan2*, Ramkrishna Sen2

, and Lı´gia R. Rodrigues1

Biosurfactants have recently emerged as promising molecules for their structural novelty, versatility, and diverse properties that are potentially useful for many

therapeutic applications. Mainly due to their surface activity, these molecules interact with cell membranes of several organisms and/or with the surrounding environments, and thus can be viewed as potential cancer therapeutics or as constituents of drug delivery systems. Some types of microbial surfactants, such as lipopeptides and glycolipids, have been shown to selectively inhibit the proliferation of cancer cells and to disrupt cell membranes causing their lysis through apoptosis pathways. Moreover, biosurfactants as drug delivery vehicles offer commercially attractive and scientifically novel applications. This review covers the current state-ofthe-art in biosurfactant research for therapeutic purposes, providing new directions towards the discovery and development of molecules with novel structures and diverse functions for advanced applications.

Hoping this will be helpful,

Rafik

Thank you so much 

Its very helpful 

Yes there are.  You can see the example given below

"Effects of biosurfactants on the viability and proliferation of human breast cancer cells" Find the attached article.

The answer is "Yes". Please go through the following RG links and PDF attachment.

Article Anticancer Activities of Surfactin and Potential Application...

Article Evaluation of anti-cancer, anti-microbial and anti-biofilm p...

Article Effects of biosurfactants on the viability and proliferation...

Working Paper Inhibition of Cancer Cells Line by Biosurfactant Produced fr...