Hi, I am trying to research in breast cancer. Can you explain therapeutic trials and bioinformatics are related? How? how bioinformatics is involved with breast cancer research. what is the major issue of the breast cancer now a days?
Dear Hetal,
This is a very general question, but some things you should take into consideration:
Cancer research in general is closely related to bioinformatics, various technologies such as microarray, Whole Exome Sequencing, proteomic use bioinformatics to analyze data, to better understand them, to analyze the related pathways, to build network of protein interactions Today, it is difficult to think of researching cancer, or any other disease without using a bioinformatic tool.
I believe these articles can help you:
https://www.cancer.gov/research/nci-role/bioinformatics
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424139/
https://link.springer.com/chapter/10.1007%2F978-90-481-2675-0_12
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179275/
Best regards,
Leite
First do a literature study. Findout the proteins that play a mojor role in the breast cancer, download those structures in NCBI. You can check the efficiency of your compounds or drugs through insilico docking analysis. Its time and money saving. Through this unwarranted clinical trails can be avoided.
I work on PIK3CA protein, this is one of the major causes for breast cancer. You can checkout my research articles.
Article Role of E542 and E545 missense mutations of PIK3CA in breast...
https://www.ncbi.nlm.nih.gov/pubmed/26827608
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