Has anyone coupled the Integrion HPIC with the MSQ mass spec? I had a go at by using an AXP pump to run water into the suppressor and an AXP-MS pump to run acetonitrile into the MSQ. The sample goes pass through the a guard column (Ionpac AG18) and separation column (Ionpac AS18) respectively into the conductivity detector before mixing with acetonitrile into the MSQ. I tested the system with 10 ppm fluoride solution in SIM mode at 39.10 m/z. This was detected by the conductivity detector but not the MSQ. I also noticed that at the end of the run, the sequence cannot be terminated and it keeps saying the injection is running even though it had finished a long time ago. Any suggestion?
Why are you looking for fluoride in SIM at m/z 39.10 amu; isn't that for potassium in positive ion mode? Fluoride should be @ m/z 19.00 amu in negative ion mode. Fluoride might be too volatile to give a good signal. I have seen Cl, Br, and I on other mass spectrometers in negative ion mode by direct infusion.
Bruce,
The predominant form of fluoride after exiting the suppressor is HF2- which has a mass of 39.1
Chris
Which versions of software are you using? We have validated the MSQ-Plus with the Integrion system under the following software versions:
Chromeleon 7.2 SP4
Foundation 3.0 SP2
MSQ 2.0 SP4
If you are running lower versions of any of these I recommend you contact your ULS service engineer and have them upgrade your software versions.
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