IP of various diseases varies. IP depends on many factors like route of inoculation, rate of replication, host susceptibility and so on. Is there any influence of IP on determining the natural history / course of a disease?
Disease expression comes based on inocula multiplication at a particular site. If it is systemic sufficient amount of inocula it should generate. Otherwise it becomes asymptomatic and stagnates in pockets and express different disease in human beings
During the incubation period inoculum or viger will be more .During this period any appropriate host or substrate comes in comntact the disease will spread'