In which part of monolocal antibodys the oxidation have effect on its biological activity ?

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Michael G. Weller

All parts of an antibody can be oxidized, particularly sensitive is the amino acid methionine. If you know the full sequence of the antibody, or even the 3-dimensional structure, you may be able to make better estimations.

Furthermore, it is important to know the oxidant.

Don Kaiser

https://tools.thermofisher.com/content/sfs/brochures/AN-21069-LC-MAbPac-HIC-20-Oxidized-mAb-Separation-AN21069-EN.pdf