Different antibiotic has different tissue penetration abilities. That is why to treat deep tissue infections, need to be chosen such an antibiotic that could penetrate deep into the tissue to reach where pathogens are colonized or have produced infections and to kill them.
For example, Ciprofloxacin is known for its deep tissue penetration (almost 70%) and that is why it is widely used to treat deep infections such as Shigellosis (infected in the very deep of intestine by Shigella dysenteriae).
Yehia A.-G. Mahmoud
Go through this link, which might be helpful: https://doi.org/10.1093/clinids/3.1.45
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