In cancer like disease, what kind of mutations are more focussed? Single Nucleotide Polymorphism or multiple mutations that occur in same gene?

01 January 2017 1 4K Report

I am trying for a comparative breast cancer study across all population focusing on mutations in gene. So, in disease like cancer, mainly what type of mutations are focussed? Multiple mutation taking place in a gene can not observed in entire population, but SNPs (may be in different region; chromosome location) are observed in common

Frederic Lepretre

In cancer you can have every possible variations, from single variants to multiple variants in one/more genes, in addition to structural variations (as Bcr/Abl or loss and gains in major genes). I forgot the epigenetics......take a look at the cosmic database to download what you need (http://cancer.sanger.ac.uk/cosmic).

fred

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