i will examine the soluble form of negative immune checkpoint inhibitors ....
my question
what the function of membraneous PD-1
and what be the function of soluble PD-1????????
and as well as
what the function of CD4 membrane bound and soluble form of CD4 what be the function in peripheral circulation?
is presence as a metabolic process or cell aging process or its presence have a unique purpose? what regulates the level of membrane form and soluble form for any immune marker
A type of drug that blocks proteins called checkpoints that are made by some types of immune system cells, such as T cells, and some cancer cells. These checkpoints help keep immune responses from being too strong.
exactly dear doctor Aqeel K. Hatem I thanks firstly for your comment
and what I want to understand in a clear way
what the aim of measure the concentration soluble form of the immune checkpoint?
is the soluble level will reflect the normal expression in the site of inflammation, tumor in concern to receptor and ligand?
I think the term of microenvironment make the soluble form in peripheral circulation not involved (not affected) in another part of the body particularly before spreading of inflammation or tumor metastasis.
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