I'm trying pirfenidone in a model of doxorubicine induced nephropathy in wistar rats. Our pirfenidone group doesn't seem good. Does reducingdose help?

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Adam B Shapiro

In what way is your pirfenidone group unsatisfactory?

Suleyman Koz

They have more than expected weight loss

Please see page 15 of this document for toxicology of this drug.

http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/002154/WC500103073.pdf

It could be too much pirfenidone. In this paper, rats were fed a diet containing 0.6% pirfenidone. It doesn't say in the abstract how much pirfenidone they actually ingested.

https://www.ncbi.nlm.nih.gov/pubmed/14564477