Generally, IFN-g levels are very high in tuberculosis patients. And it is expected that pro-inflammatory cytokines will be at higher end while anti-inflammatory will be at the lower end. I have come across a study where they found low levels of IFN-g in TB patients' samples (n
Circulating IFNg levels? I don't know about very high. Usually they are significantly increased but I won't considered them very high. The IFNg at the site of infection is much higher.
You have to post the paper, or post the title and authors. How did they define TB patients, LTBI or active, untreated?
Data is not published yet.
Yeah circulating IFN-g levels. Also, it doesn't find a significant difference for other pro-inflammatory cytokines but Th2 cytokines were significantly low.
Groups are Active TB patients and non-TB patients(similar symptoms to TB) and Healthy subjects. No LTBI group.
All the TB and non-TB groups are drug-naive.
Did they see a difference in the non-TB patients? If there is nothing wrong with their data collection, protocols, or analysis, then it is what it is.
It is a small study... so it might be just an unique observation.
I mean... it is possible... since during active TB disease, the IFNg producing cells localize to the site of the disease. And since the TH2 cytokines were also low does suggest a migration of T cells from circulation to the lungs.
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