I think understanding the periodontal-orthodontic interrelation may give some light in this topic.
Following papers may help
1. Vanarsdall, R. L. (1994). Periodontal/orthodontic interrelationships. In Orthodontics: current principles and techniques (pp. 801-838). Mosby, St Louis.
2. Dannan, A. (2010). An update on periodontic-orthodontic interrelationships. Journal of Indian Society of Periodontology, 14(1), 66.
The aetiology and parthenogenesis of bony changes in orthodontics (mechanical) are very different from those seen in periodontitis (bacterial-host interaction). In animal studies, ligatures are often tied around teeth to induce periodontitis but the aim of the ligature is to increase the microbial load locally, as opposed to exerting a mechanical force on the tooth/PDL.
The patho-physiology of periodontal disease and the process of periodontal changes during orthodontic treatment are different so I don't agree that one can be used to mimic the other. That in itself introduces a bias to the study.