LD 50 in mice was reported as 180 mg/Kg
MIC in vitro 320 micro gram/ml
what is the requirement to insure safety for future pilot study in human
Please go through the attached guideline. Human trials can't be initiated on the basis of data you have provided.
See Table 1 in the guideline: the duration of repeat dose-toxicity studies in animals needed to support clinical trial of particular duration
First you need to calculate safety index in-vivo.
Kaempferol , i plan to use this compound to ameliorate adverse effects of some drugs , substrate for P-GP
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