Kaempferol , i plan to use this compound to ameliorate adverse effects of some drugs , substrate for P-GP
Here are a few references on the interaction of kaempferol and other flavonoids on P-gp.
Article Inhibition of P-Glycoprotein Function and Expression by Kaem...
Article Modulation of P-glycoprotein-mediated resistance by kaempfer...
The situation can get complicated. A substance can be an inducer of expression of P-gp or other efflux systems, a substrate for transport, an inhibitor by competing with another transport substrate, or an activator of transport by another substrate, or a combination of those things.
Hi,
truthfully, it's all a matter of concentration. Quercetin, for instance, has been described as substrate and modulator for P-gp, depending on what you are searching.For kaempferide and flavonoids in general, please check this articles, they may help:
1. Conseil G, Baubichon-Cortay H, Dayan G, Jault J-M, Barron D, Pietro A Di, et al. Flavonoids: A class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein. Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9831–6.
2. Conseil G, Decottignies A, Jault J-MM, Comte G, Barron D, Goffeau AA, et al. Prenyl-Flavonoids as Potent Inhibitors of the Pdr5p Multidrug ABC Transporter from Saccharomyces cerevisiae †. Biochemistry [Internet]. 2000 Jun 13 [cited 2011 Jun 28];39(23):6910–7.
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