.. I want to check that binder and drug release through the tablets coated by the gum.. Kindly tell me the amount of gum as binder in each tablet. I have studied alot literature they have not mentioned that just written wet method or direct compression method used and sample and salt are grinded well .. they have not mentioned quantity .. Kindly Help me!
thanks alot sir Actually my plan is i want to use 400mg pure salt of model drug 1% lubricating agent , 10% filler , 5% disintegrant and 100mg gum as binder in each is it correct or I should decrease the quantity of binder ??
Hi,
It depends on your tablet's final weight, 10% binder is a maximum but don't forget that natural gums used as binders can also act as disintegrant (agar gum, guar gum), may be you can also decrease the disintegrant...
Yes we have to consider the total weight of tablet. I have a publication which may be helpful (attached).
Hi. The amount and the type of the binder used influences hardness, disintegration time, and friability of tablets. Moreover the an effect on drug release can be detected. In my opinion you should use different percentages in order to find the most appropriate.
Thanks Sir @Anroop Nair and thank alot Mis @Cinzia Pagano for your kind comments!
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