I have two strains A and B. I grow them in a media for 0-24 hrs and took reading at every 30 mints. I plotted these values on a graph (Y=O.D and X=Time). I want to see the significance difference among values at a particular time point. Can anyone suggest me which statistics should I use to get significant difference?
Multilevel/mixed models or latent growth curve analysis may help you.
Dear colleague
Several methods have been proposed for analyzing growth curves. Much of the literature and some PCA-Based methods are discussed in the following papers.
Snee, R. D. (1972) "On the Analysis of Response Curve Data", Technometrics, V14, No.1, 47-62.
Snee, R. D. (1979) "A Useful Method for the Analysis of Growth Curves", Biometrics, v35, No. 4, 835-848.
Y. Wnag, R. D. Snee, G. Keyvan and F. J. Muzzio (2015) “Statistical Comparison of Dissolution Profiles”, Drug Development and Industrial Pharmacy, Online, August 2015.
Regards
You can do the stats, but to the eye it is clear that the difference in growth rates between the 2 strains is negligible.
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